Isaac Ison b 1785; s/o Charles Ison and Elizabeth Jane Jones. Isaac Ison m. 2 Jan 1822 Scott Co VA to Rebecca A Ingram b 1794 Scott Co VA. Children of Isaac Ison and Rebecca A Ingram;

1. Archibald Ison b 1816 Scott Co VA d 21 Dec 1894 Wise Co VA; m. 26 Jan 1835 Hawkins TN to Margaret Hunsucker b 1819 TN; d/o George Hunsucker and Willy Nellie Ann Gardner.

2. Edmond Ison b abt 1817 Scott Co VA d 1881 Pike Co KY; m. Cassie Huff b abt 1820 Russell Co VA. Children of Edmond Ison and Cassie Huff; i. Sarah Ison b 20 Jun 1840 VA ii. Mahulda Ison b 2 Jul 1842 VA iii. Mary Ison b abt 1847 iv. Margaret Ison b 22 Sept 1852 v. Oma Ison b 22 Sept 1852 VA vi. Alexander Ison b 26 Jan 1854 VA vii. David D Ison b 19 Aug 1856 VA viii. William M Ison b 29 Feb 1859 Shelby Gap, Pike Co KY ix. Rebecca Ann Ison b 25 Aug 1861 Jenkins, Letcher Co KY

3. Elizabeth Ison b 1821 TN; m. 20 Jul 1837 Mount Pleasant, Maury Co TN to George Washington Mitchell b 5 Mar 1815 NC d 6 Apr 1904; s/o James C Mitchell and Mary Craig.

4. Wilson P Ison b 1828 VA; m. Frances Whitaker b 2 Dec 1831 Floyd Co KY d 22 Aug 1903; buried Clint Ison Cemtery, Skyline, Letcher Co KY; d/o Isaac Whitaker and Susannah Rice.

5. Isaac Ison b 1830 VA; occupation, blacksmith; m. Margaret Peggy Creech b 1835 VA

6. Mary Ann Ison b 1832 VA

7. Ursula Ison b 1835 TN

8. Scott Ison b abt 1837 VA

1860 Wise Co VA Census
684 Ison, Archibald 44 M Farmer VA
684 Ison, Margaret 40 F Housekeeper TN
684 Ison, George 22 M Farm Hand VA
684 Ison, Edmond 20 M Farmhand VA
684 Ison, James 18 M Farmhand VA
684 Ison, Landon C 16 M VA
684 Ison, Ann 21 F Seamstress VA

685 Ison, Isaac 75 M Farmer VA
685 Ison, Rebecca A 64 F Housekeeper VA
685 Ison, Asoto? 20 M Farmhand VA